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No participants in the MEDI0382 group had a grade 3 or worse TEAE (vs two [8%] in the placebo group)

[10] [11] Interleukin-6 (IL-6): A cytokine involved in acute-phase inflammatory responses

Most cardiac E3 ligases belong to the RING-type family, although both single- and multi-subunit variants exist, each executing distinct regulatory roles

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