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Use of GLP-1RAs in an AD mouse model has also shown a neuroprotective role in promoting a reduction in glutamate-induced currents [64]

Clinical investigations further confirmed that GLP-1RA treatment led to significant improvements in key pulmonary function parameters, including forced expiratory volume in one second (FEV 1 ), forced vital capacity (FVC), and mid-expiratory flow rates (MEF 75 and MEF 50 )

While lixisenatide is only available outside of the US, exenatide is commercially available twice daily in both Europe and the US

Ethics declarations Ethics Approval NIPERA/IAEC/2019/16 Research Involving Human Participants and/or Animals This study was performed in accordance with CPCSEA guidelines

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