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Availability of data and materials Data sharing is not applicable to this study as data management and analysis were only allowed to be conducted in Health and Welfare Data Science Center in Taiwan for data privacy and safety concerns

Patients experience symptoms including bloody diarrhoea, abdominal pain, urgency, and fatigue

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Furthermore, a recent study emphasized that supplementation with CysSSH protected macrophages from DAMPs-induced pyroptosis by modulating NLRP3 persulfidation, providing valuable insights into the regulatory role of supersulfides in inflammasome activation (113) ( Figure 10 )

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