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ADX47273 - CAS# 851881-60-2 0127 918633-87-1

ADX47273 - CAS# 851881-60-2 0127 918633-87-1

Name: ADX47273 - CAS# 851881-60-2 0127 918633-87-1
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SKU: 75549891713
Price: 89.00 USD
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SKU: 75549891713

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ADX47273 - CAS# 851881-60-2 0127 918633-87-1ADX 47273, CAS No. 851881 60 2, is a potent and selective mGluR5 receptor PAM (positive allosteric modulator), EC50 = 0. 17 m, with no effect on other mGluR subtypes. In vivo, ADX47273 increased extracellular signal regulated kinase and cAMP responsive element binding protein phosphorylation in hippocampus and prefrontal cortex, both of which are critical for glutamate mediated signal transduction mechanisms. The mGluR (metabotropic glutamate

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Description

918633-87-1

is a brain penetrant

Smiles: CN(C1=CC(=CC=C1)C1=CC=NC2=C(C=NN12)C(=O)C1=CC=CS1)C(C)=O

IOX4 was used at 10-50 µM final concentration in vitro and in cellular assays

WS3 was used at 0

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