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In susceptible patients, these pressures may increase mitochondrial stress, raise SAH, lower the SAM-to-SAH ratio and create a functional undermethylation pattern that contributes to depression, anxiety, brain fog, fatigue and medication sensitivity

Glutathione alterations in depression: A meta-analysis and systematic review of proton magnetic resonance spectroscopy studies Hu, X., et al

After 6 months, methylmalonic acid (MMA) levels, the most specific marker for B12 activity of a food or supplement, went from 164 nmol/l to 169 nmol/l which is essentially no change and by itself would indicate no benefit of the multivitamin

Use glutathione as one part of a broader routine, alongside sunscreen and hydration, rather than a standalone fix

This is either the real deal or the most elaborate placebo effect Ive ever experienced