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This selective permeability presents challenges in treating brain diseases, as medications that could benefit the brain cant always cross into it

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T., Clemmons, D., Bellush, L

In another study, when comparing T1D C-peptide positive pre-pubertal children and adults vs their C-peptide negative counterparts, patients with a residual -cell function had higher IGF-I levels despite similar glycemic control (47, 48)

Interestingly, a recent study examining the time-dependent effect of low IGF-1 levels on aging outcomes observed that a targeted reduction in liver-derived IGF-1 early (10 d or 5 mo) or later in life (15 mo) improved aspects of lifespan in females, though these effects were most pronounced when IGF-1 was reduced at 5 mo old 19