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2015;66(Suppl 3):103

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A direct detrimental incretin effect on the central nervous system could also be hypothesized and susceptible people receiving GLP-1 RAs may, in some circumstances, experience a worsening of hedonic tone predisposing psychopathology and/or self-harm ideation and/or other aspects of suicidality

Adequate hydration is important, with fluid needs varying by individual factors including activity level, climate, and health conditions