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Declarations Authors contributions Designed the paper, selected and prepared the references, prepared the figures, wrote the manuscript: Wright JW Prepared the references, wrote the manuscript: Harding JW Availability of data and materials Not applicable

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THEY ARE NOT IN A STERILE SOLUTION OR FOR INJECTION

For initial trials, a lower dose of 100-250 mcg is recommended, with adjustments made based on the subjects response and study objectives

However, in contrast to rhEPO that has shown side effects in clinical trials, to date ARA 290 has been shown to be safe when formally evaluated in preclinical animal toxicology, normal human volunteers and patients with sarcoidosis (1921)