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Additionally, the extract downregulated the apoptotic markers in HCECs, suggesting a preventive function against cell death [73]

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Dysregulation of BA metabolism occurs when any component of BA synthesis, secretion, or reabsorption, or microbial modification becomes impaired

Patients were randomized to follow a therapeutic cycle for a total period of eight years: citicoline (1,000 mg/day, by intramuscular injection) or placebo (-blockers alone) for a two-month period followed by a four-month washout period (87)