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In mutant SOD1, these aberrant disulfide bonds involve cysteine residues Cys 6 and Cys111, and in both mutant and WT TDP-43, cysteines Cys173, 175, 198, and 244 in the RNA-recognition motif (RRM) are involved (Cohen et al., 2012

Brain oxidative stress induced by obstructive jaundice in rats

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Lai et al demonstrated that 2400 mg of oral NAC (1200 mg, bid) quickly increased glutathione levels in lymphocytes during a chronic inflammatory disease, which was not achieved by a low-dose NAC (600 mg, bid)