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Conversely, emerging evidence indicates that lactate can paradoxically potentiate antioxidant defense mechanisms through alternative signaling cascades

As anticipated, the dissection of apparent equilibria into elementary redox ones in biological thiol-disulfide systems reveals significant differences between reactions of apparently highly similar, covalently identical reactants, improving thus our understanding of redox homeostasis and providing new means to influence it

showed that constitutively-active FoxO3 increased protein degradation in cultured myotubes, and, surprisingly, approximately 80% of the effect was mediated by autophagy [60]

Support for sirtuin signaling pathways