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This relatively small GPCR family is characterized by a long extracellular ligand-binding domain stabilized by three disulfide bridges formed by six highly conserved cysteine residues, seven -helical transmembrane domains, universal for all GPCRs and an intracellular C-terminal domain, responsible mostly for receptor internalization due to the presence of multiple phosphorylation sites [22, 23]

Hip fractures alone hospitalize hundreds of thousands of people each year, and within a year of breaking a hip, one in four will die

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To view a copy of this license, visit About this article Cite this article Ke, J., Liu, Y., Yang, J

We used the shrinkage to measure drugdrug interactions because a previous study showed that it is the most conservative method among multiple algorithms [32]