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However, white matter OL lineage cells are more intrinsically regulated vs those in the gray matter, as transplantations into the adult mouse cerebral cortex revealed that white matter-derived cells differentiated into mature OLs in both niches with equal efficiency, whereas gray matter-derived cells did not 75

It is a tripeptide (peptide made up of 3 amino acids) made of the amino acids glycine, glutamic acid, and cysteine

First pass metabolism typically results in low bioavailability, resulting in adjusted dosages

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Thus, mitochondrial dysfunction represents a critical hub in HTN-associated OS, linking metabolic, inflammatory, and vascular pathways, and its modulation offers a novel avenue for precision therapies in resistant HTN