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Appetite changes can happen on tamoxifen, although they do not look the same for everyone You might notice feeling less hungry, getting full more quickly, or feeling less interested in food than usual These changes can be easy to miss at first, especially if they build up gradually Eating smaller amounts more regularly may feel easier than trying to manage bigger meals Keeping simple, easy foods around can help on days when eating feels more effortful It can be useful to notice whether appetite changes seem worse alongside nausea, fatigue, stress, or poor sleep If changes in appetite are ongoing, affecting your energy, or leading to noticeable weight changes, it is worth mentioning them to your care team Tracking changes over time can help you spot patterns and explain what has been happening more clearly at appointments Save this for later and download OWise to track symptoms, side effects and questions for your care team | OWise Breast Cancer

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Notably, CNS GIPR antagonism produces body weight loss in obese mice and also extends the anorectic effect of a GLP-1R agonist

[DOI] [PubMed] [Google Scholar] 64.Traish A.M

Hepatocellular hypertrophy is typically identified by light microscopy and is associated with increased protein synthesis (assessed biochemically) and increased cytoplasmic organelles such as endoplasmic reticulum and peroxisomes (assessed by electron microscopy), or accumulation of intracellular components such as glycogen, lipid, or water