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doi:10.1016/j.bcp.2015.07.012 Zhao JV, Yeung WF, Chan YH, et al

This powerful mechanism drives weight loss but can also reduce bowel movement frequency, causing constipation in roughly one in five patients during the first weeks of therapy

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10.3389/fphar.2014.00262 403

In contrast, indicator systems that specifically sense particular redox couples allow real-time observation of redox changes (Gutscher et al., The experimental difficulties to obtain reliable potentials of thiol/disulfide systems prompt further concern to accept these parameters or changes thereof as critical determinants of biological events