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[13] The current NICE obesity guideline sets out a structured approach involving lifestyle interventions as a first-line measure, licensed pharmacotherapy where clinically appropriate, and bariatric surgery for eligible individuals with severe obesity

Patients should be aware that while constipation is a common side effect, it is usually manageable with lifestyle adjustments and medical guidance

MahfoudR.MarescaM.GarmyN.FantiniJ.The mycotoxin patulin alters the barrier function of the intestinal epithelium: mechanism of action of the toxin and protective effects of glutathioneToxicol

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For instance, children with severe vitamin E deficiency from birth and are not treated with vitamin E rapidly develop neurological symptoms