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In humans, nearly all circulating GLP-1 is one of the latter two forms (89)

The article's comparison puts osmotic agents such as polyethylene glycol at roughly 12 to 24 hours and describes them as first-line, stimulant agents such as senna at 6 to 12 hours but carrying dependence risk with chronic overuse, stool softeners at 24 to 72 hours with a mild effect best used as an adjunct, and prescription secretagogues at 24 to 48 hours